“We found that the small molecule binds to a hidden pocket in hemagglutinin,” said study first author Rameshwar U. Kadam, senior research associate at TSRI. He added that the drug acts as a sort of “glue” to hold the subunits of hemagglutinin together. “Arbidol is the first influenza treatment shown to use a hemagglutinin-binding approach,” he said. This vulnerable pocket is “conserved,” meaning it is likely important for viral function–and more difficult to mutate as the virus spreads–suggesting why Arbidol has relatively broad use in fighting many strains of the virus, including emerging strains. The new findings also help scientists understand how Arbidol compares to influenza treatments such as Tamiflu. Wilson explained that Tamiflu prevents the virus from getting out of cells, while Arbidol prevents it from getting in. This means Arbidol, or future drugs that take a similar approach, could be given as a preventative treatment before an outbreak hits. “When we had the 2009 H1N1 pandemic, the vaccine came too late,” said Wilson. “If we had a front-line therapeutic, that could have worked much better until a vaccine was ready.” Wilson said the next step for researchers is to discover and/or design other small molecule therapeutics that can bind even more tightly with the hemagglutinin. ### This study, “Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol,” was supported by the http://stellamooredesign.chicagodocfestival.org/2016/09/19/the-anti-aging-dry-oily-skin-care-products-help-you-to-trim-down-all-the-problems-that-you-have-because-of-aging-dry-oily-skin National Institutes of Health (grant R56 AI117675) and an Early Mobility Postdoctoral Fellowship from the Swiss National Science Foundation.
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Jeffrey Ecker, MD, chief of Obstetrics and Gynecology at MGH, says, “Information like this helps obstetric providers know what to be vigilant for in pregnant women with a history of acute kidney injury and indicates that asking about such history is important. Being especially watchful for signs and symptoms of preeclampisa in such patients is one immediate application of this work. In a longer view, work like this offers important hypotheses for future study. Thank You Can interventions in patients with a history of acute kidney injury prevent complications like preeclampsia? Taking a baby aspirin each day during pregnancy is recommended for some women at high risk for preeclampsia. Should such preventative treatment be used in women with a history of acute kidney injury? Questions like this deserve further thought and study.” ### Ravi Thadhani, MD, MPH, chief of the MGH Division of Nephrology and a professor of Medicine at Harvard Medical School, is senior author of the Journal of the American Society of Nephrology report. Additional co-authors are Camille Powe, MD, MGH Division of Endocrinology; Elizabeth Ankers, MGH Division of Nephrology; Kate Bramham, MD, PhD, King’s College London; Michelle Hladunewich, MD, MS, University of Toronto; and Ananth Karumanchi, MBBS, Beth Israel Deaconess Medical Center, Boston. The study was supported by National Institutes of Health Ta grants T32 DK007540-30, T32 DK007028-41 and K24 DK094872-05. Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School.http://crazywyattperry.techno-rebels.com/2016/11/13/because-if-you-have-a-children-you-can-find-all-the-special-care-for-your-baby-and-a-special-relax-for-yourself
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